Skip to main content
Erschienen in: Virchows Archiv 4/2021

14.05.2021 | Original Article

High-risk individuals for gastric cancer would be missed for surveillance without subtyping of intestinal metaplasia

verfasst von: Sergejs Isajevs, Selga Savcenko, Inta Liepniece-Karele, Maria Blanca Piazuelo, Ilze Kikuste, Ivars Tolmanis, Aigars Vanags, Indra Gulbe, Linda Mezmale, Darhan Samentaev, Altynbek Tazedinov, Ramis Samsutdinov, Tatjana Belihina, Nurbek Igissinov, Marcis Leja

Erschienen in: Virchows Archiv | Ausgabe 4/2021

Einloggen, um Zugang zu erhalten

Abstract

The use of Operative Link on Gastritis Assessment (OLGA) and Operative Link on Gastritis Assessment based on Intestinal Metaplasia (OLGIM) staging system is recommended for identifying subjects at risk for developing gastric cancer; usually high-risk lesions are considered only as stages III and IV. Accumulating evidence suggests that incomplete intestinal metaplasia (IM) is important in the development of gastric cancer. Our aim has been to identify the prevalence of incomplete IM in patients with low-risk OLGA/OLGIM stages among a high-risk general population. Healthy adult volunteers aged 40–64 years were invited to undergo upper endoscopy within a regional GISTAR pilot study in Kazakhstan (n = 166). Gastric lesions were staged according to OLGA/OLGIM staging system. High iron diamine–alcian blue (HID-AB) was used for subtyping IM. IM prevalence overall was 45.8%. Incomplete IM was present in 52.6% (type II in 30.3% and type III in 22.3%), whereas complete IM was found in 47.4% individuals. The prevalence of OLGIM I and II stage were 39.8 and 4.8%, respectively, whereas OLGIM III was observed in 1.2%. The prevalence of incomplete IM in patients stratified to OLGIM I was 54.5% (type II in 31.8% and type III in 22.7%). High prevalence of incomplete IM was detected not only in subjects with extensive IM, but in those stratified as at the OLGIM I stage. Without IM subtyping, patients with high risk of gastric cancer development would be missed for surveillance.
Literatur
1.
Zurück zum Zitat Pimentel-Nunes P, Libanio D, Marcos-Pinto R et al (2019) Management of epithelial precancerous conditions and lesions in the stomach (MAPS II): European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter and Microbiota Study Group (EHMSG), European Society of Pathology (ESP), and Sociedade Portuguesa de Endoscopia Digestiva (SPED) guideline update. Endoscopy 51(4):365–388. https://doi.org/10.1055/a-0859-1883CrossRefPubMed Pimentel-Nunes P, Libanio D, Marcos-Pinto R et al (2019) Management of epithelial precancerous conditions and lesions in the stomach (MAPS II): European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter and Microbiota Study Group (EHMSG), European Society of Pathology (ESP), and Sociedade Portuguesa de Endoscopia Digestiva (SPED) guideline update. Endoscopy 51(4):365–388. https://​doi.​org/​10.​1055/​a-0859-1883CrossRefPubMed
11.
Zurück zum Zitat Tulassay Z, Stolte M, Engstrand L et al (2010) Twelve-month endoscopic and histological analysis following proton-pump inhibitor based triple therapy in Helicobacter pylori-positive patients with gastric ulcers. Scand J Gastroenterol 45:1048–1058CrossRef Tulassay Z, Stolte M, Engstrand L et al (2010) Twelve-month endoscopic and histological analysis following proton-pump inhibitor based triple therapy in Helicobacter pylori-positive patients with gastric ulcers. Scand J Gastroenterol 45:1048–1058CrossRef
12.
Zurück zum Zitat Yeh LY, Raj M, Hassan S, Aziz SA, Othman NH, Mutum SS, Naik VR (2009) Chronic atrophic antral gastritis and risk of metaplasia and dysplasia in an area with low prevalence of Helicobacter pylori. Indian J Gastroenterol 28:49–52CrossRef Yeh LY, Raj M, Hassan S, Aziz SA, Othman NH, Mutum SS, Naik VR (2009) Chronic atrophic antral gastritis and risk of metaplasia and dysplasia in an area with low prevalence of Helicobacter pylori. Indian J Gastroenterol 28:49–52CrossRef
14.
Zurück zum Zitat Correa P, Haenszel W, Cuello C, Zavala D, Fontham E, Zarama G, Tannenbaum S, Collazos T, Ruiz B (1990) Gastric precancerous process in a high risk population: cross-sectional studies. Cancer Res 50:4731–4736PubMed Correa P, Haenszel W, Cuello C, Zavala D, Fontham E, Zarama G, Tannenbaum S, Collazos T, Ruiz B (1990) Gastric precancerous process in a high risk population: cross-sectional studies. Cancer Res 50:4731–4736PubMed
15.
Zurück zum Zitat Filipe MI, Munoz N, Matko I, Kato I, Pompe-Kirn V, Jutersek A, Teuchmann S, Benz M, Prijon T (1994) Intestinal metaplasia types and the risk of gastric cancer: a cohort study in Slovenia. Int J Cancer 57:324–329CrossRef Filipe MI, Munoz N, Matko I, Kato I, Pompe-Kirn V, Jutersek A, Teuchmann S, Benz M, Prijon T (1994) Intestinal metaplasia types and the risk of gastric cancer: a cohort study in Slovenia. Int J Cancer 57:324–329CrossRef
20.
Zurück zum Zitat Matsukauma A, Mori M (1990) Sulphomucin-secreting intestinal metaplasia in the human gastric mucosa. Cancer 66:689–694CrossRef Matsukauma A, Mori M (1990) Sulphomucin-secreting intestinal metaplasia in the human gastric mucosa. Cancer 66:689–694CrossRef
29.
Zurück zum Zitat Lin CK, Lai KH, Lo GH, Cheng JS, Hsu PI, Mok KT, Tseng HH (2001) Cathepsin E and subtypes of intestinal metaplasia in carcinogenesis of the human stomach. Zhonghua Yi Xue Za Zhi 64:331–336PubMed Lin CK, Lai KH, Lo GH, Cheng JS, Hsu PI, Mok KT, Tseng HH (2001) Cathepsin E and subtypes of intestinal metaplasia in carcinogenesis of the human stomach. Zhonghua Yi Xue Za Zhi 64:331–336PubMed
37.
Zurück zum Zitat Kulmambetova GN, Imanbekova MK, Logvinenko AA, Sukashev AT, Filipenko ML, Ramanculov EM (2014) Association of cytokine gene polymorphisms with gastritis in a Kazakh population. Asian Pac J Cancer Prev 15:7763–7768CrossRef Kulmambetova GN, Imanbekova MK, Logvinenko AA, Sukashev AT, Filipenko ML, Ramanculov EM (2014) Association of cytokine gene polymorphisms with gastritis in a Kazakh population. Asian Pac J Cancer Prev 15:7763–7768CrossRef
38.
Zurück zum Zitat Benberin V, Bektayeva R, Karabayeva R, Lebedev A, Akemeyeva K, Paloheimo L, Syrjänen K (2013) Prevalence of H. pylori infection and atrophic gastritis among symptomatic and dyspeptic adults in Kazakhstan. A hospital-based screening study using a panel of serum biomarkers. Anticancer Res 33:4595–4602PubMed Benberin V, Bektayeva R, Karabayeva R, Lebedev A, Akemeyeva K, Paloheimo L, Syrjänen K (2013) Prevalence of H. pylori infection and atrophic gastritis among symptomatic and dyspeptic adults in Kazakhstan. A hospital-based screening study using a panel of serum biomarkers. Anticancer Res 33:4595–4602PubMed
42.
Zurück zum Zitat Ozdil K, Sahin A, Kahraman R, Yuzbasioglu B, Demirdag H, Calhan T, Yuzbasioglu B, Demirdag H, Calhan T, Muberra S, Yilmaz H, Sokmen M (2010) Current prevalence of intestinal metaplasia and Helicobacter pylori infection in dyspeptic adult patients from Turkey. Hepatogastroenterology 57:1563–1566PubMed Ozdil K, Sahin A, Kahraman R, Yuzbasioglu B, Demirdag H, Calhan T, Yuzbasioglu B, Demirdag H, Calhan T, Muberra S, Yilmaz H, Sokmen M (2010) Current prevalence of intestinal metaplasia and Helicobacter pylori infection in dyspeptic adult patients from Turkey. Hepatogastroenterology 57:1563–1566PubMed
Metadaten
Titel
High-risk individuals for gastric cancer would be missed for surveillance without subtyping of intestinal metaplasia
verfasst von
Sergejs Isajevs
Selga Savcenko
Inta Liepniece-Karele
Maria Blanca Piazuelo
Ilze Kikuste
Ivars Tolmanis
Aigars Vanags
Indra Gulbe
Linda Mezmale
Darhan Samentaev
Altynbek Tazedinov
Ramis Samsutdinov
Tatjana Belihina
Nurbek Igissinov
Marcis Leja
Publikationsdatum
14.05.2021
Verlag
Springer Berlin Heidelberg
Erschienen in
Virchows Archiv / Ausgabe 4/2021
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-021-03116-3

Weitere Artikel der Ausgabe 4/2021

Virchows Archiv 4/2021 Zur Ausgabe

Neu im Fachgebiet Pathologie